Endogenous pyrogen production by Hodgkin's disease and human histiocytic lymphoma cell lines in vitro.

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Endogenous pyrogen production by Hodgkin's disease and human histiocytic lymphoma cell lines in vitro.

Fever not explained by infection may occur in patients with malignant lymphoma presumably caused by a release of endogenous pyrogen. Although pyrogen has been found in some tumors with a mixed cell population, production of endogenous pyrogen by the neoplastic cells has not been demonstrated. This report documents the apparently spontaneous synthesis and release of such pyrogen by two human tum...

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ژورنال

عنوان ژورنال: Journal of Clinical Investigation

سال: 1980

ISSN: 0021-9738

DOI: 10.1172/jci109695